孔武有力的夏侯武（甄子丹 饰）曾是佛山武馆合一门的弟子，当年他争强好胜，在香港担任教官时与他人比武，结果失手将对方打死最终锒铛入狱
三年后的某天，闹市街头发生一宗离奇车祸，死者似乎在车祸前就被武功高强之人残忍杀害 夏侯武在狱中看到该新闻，心知在此背后有一场针对武林中人的猎杀正有条不紊地展开 他强烈要求面见重案组总督察陆玄心（杨采妮 饰），由于言中接下来命案的遇害者，终于取得陆督察的信任，得以协助警方办案 与此同时，先天残疾却练得一身绝技的封于修（王宝强 饰）四处挑战隐于闹市的高手，更在获胜后将他们无情杀害
武林波涛汹涌，夏侯武和封于修迎来对决的终极时刻……
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